Sperm fluorescence in situ hybridization study of meiotic segregation and an interchromosomal effect in carriers of t(11;18)

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Sperm fluorescence in situ hybridization study of meiotic segregation and an interchromosomal effect in carriers of t(11;18).

BACKGROUND Alanced translocations are associated with infertility, spontaneous abortions and birth defects. METHODS We report the analysis, by multicolour fluorescence in situ hybridization (FISH), of meiotic segregation and aneuploidy of chromosomes X, Y, 7, 8 and 21 in sperm from three men who are carriers of two different translocations involving chromosomes 11 and 18. A control group comp...

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ژورنال

عنوان ژورنال: Human Reproduction

سال: 2008

ISSN: 0268-1161,1460-2350

DOI: 10.1093/humrep/dem345